The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions. The Cardiovascular Risk in Young Finns Study

نویسندگان

چکیده

Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport oxidized lipids by high-density (HDL) contribute to atheroprotection. To provide insights into associations lipid oxidation markers with subclasses at population level, we investigated HDL (oxHDLlipids) and LDL (oxLDLlipids) in a population-based cross-sectional study 1395 Finnish adults ages 24–39 years. The analysis was based on determination baseline level conjugated dienes lipids. A high-throughput nuclear magnetic resonance (NMR) platform used quantify circulating subclass concentrations analyze their compositions. OxHDLlipids were mainly not associated composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference age. OxLDLlipids several Apolipoprotein-B (Apo-B), age circumference. Several measures subclasses, including phospholipid triglyceride composition, directly oxLDLlipids. Cholesterol ester free cholesterol inversely We conclude that these results do support idea HDL's particle size or would reflect its functional capacity On contrary, oxLDLlipids entire profile, numerous compositional descriptors particles. This is line suggested role atherogenesis.

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ژورنال

عنوان ژورنال: Free Radical Biology and Medicine

سال: 2021

ISSN: ['1873-4596', '0891-5849']

DOI: https://doi.org/10.1016/j.freeradbiomed.2020.10.020